ClaNC: point-and-click software for classifying microarrays to nearest centroids

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ClaNC: point-and-click software for classifying microarrays to nearest centroids

SUMMARY ClaNC (classification to nearest centroids) is a simple and an accurate method for classifying microarrays. This document introduces a point-and-click interface to the ClaNC methodology. The software is available as an R package. AVAILABILITY ClaNC is freely available from http://students.washington.edu/adabney/clanc

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BIOINFORMATICS Classification of Microarrays to Nearest Centroids

Motivation: Classification of biological samples by microarrays is a topic of much interest. A number of methods have been proposed and successfully applied to this problem. It has recently been shown that classification by nearest centroids provides an accurate predictor that may outperform much more complicated methods. The ”Prediction Analysis of Microarrays” (PAM) approach is one such examp...

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Classification of microarrays to nearest centroids

MOTIVATION Classification of biological samples by microarrays is a topic of much interest. A number of methods have been proposed and successfully applied to this problem. It has recently been shown that classification by nearest centroids provides an accurate predictor that may outperform much more complicated methods. The 'Prediction Analysis of Microarrays' (PAM) approach is one such exampl...

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We propose a new method for class prediction in DNA microarray studies, based on an enhancement of the nearest prototype classi er. Our technique uses \shrunken" centroids as prototypes for each class and identi es the subsets of the genes that best characterize each class. The method is general, and can be used in other high-dimensional classi cation problems. The method is illustrated on data...

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Nearest shrunken centroids (NSC) is a popular classification method for microarray data. NSC calculates centroids for each class and "shrinks" the centroids toward 0 using soft thresholding. Future observations are then assigned to the class with the minimum distance between the observation and the (shrunken) centroid. Under certain conditions the soft shrinkage used by NSC is equivalent to a L...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2005

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/bti756